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| WilliamPl | Дата: Воскресенье, 29.03.2015, 04:34 | Сообщение # 46 |
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| Mardinem | Дата: Вторник, 31.03.2015, 07:48 | Сообщение # 47 |
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| Marianrog | Дата: Понедельник, 06.04.2015, 08:34 | Сообщение # 48 |
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| UrirlExipar | Дата: Четверг, 09.04.2015, 17:40 | Сообщение # 49 |
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Группа: Гости
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| fmyykjn | Дата: Четверг, 09.04.2015, 22:58 | Сообщение # 50 |
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Группа: Гости
| Varenicline (trade mention Chantix in the USA and Champix in Canada, Europe and other countries, marketed close to Pfizer, generally speaking in the shape of varenicline tartrate), is a remedy medication habituated to to treat nicotine addiction. Varenicline is a nicotinic receptor affinity to agonist—it stimulates nicotine receptors more weakly than nicotine itself does. In this admiration it is nearly the same tocytisine and weird from the nicotinic contender, bupropion, and nicotine replacement therapies (NRTs) like nicotine patchesand nicotine gum. As a affinity to agonist it both reduces cravings looking for and decreases the pleasurable effects of cigarettes and other tobacco products. Through these mechanisms it can abet some patients to discharged smoking.
Medical uses
Varenicline is indicated for smoking cessation. In a 2006 randomized controlled inquisition sponsored by Pfizer, after only year the figure of continuous abstinence was 10% in place of placebo, 15% instead of bupropion and 23% benefit of varenicline.[1 - In a 2009 meta-analysis of 101 studies funded near Pfizer, varenicline was establish to be more effectual than bupropion (odds ratio 1.40) and NRTs (odds ratio 1.56).[2 -
A Cochrane systematized scrutinize concluded that varenicline improved the distinct possibility of successfully quitting smoking sooner than two- to three-fold relative to pharmacologically unassisted attempts. Varenicline was more efficacious than bupropion in this appreciation but not statistically high-class to NRT.[3 -
The FDA has approved the utilize of varenicline representing up to twelve weeks. If smoking cessation has been achieved it may be continued after another twelve weeks.[4 -
Varenicline has not been tested in those under 18 years aged or preggers women and therefore is not recommended in behalf of use by these groups.
Adverse effects
Nausea occurs commonly in people winning varenicline. Other less worn out side effects embrace problem, gordian knot embarrassment sleeping, and irregular dreams. Rare side effects reported by people entrancing varenicline compared to placebo encompass change in discrimination, vomiting,abdominal soreness, flatulence, and constipation. In a modern meta-analysis sheet a documents at near Leung et al., it has been estimated that due to the fact that every five subjects bewitching varenicline at sustentation doses (1 mg twice common), there will be an experience of nausea, and in spite of every 24 and 35 treated subjects, there wishes be an at any rate of constipation and flatulence respectively. Gastrointestinal side-effects are portentous factors compromising the compliance of varenicline.[5 - [6 -
Bust and suicide
In November 2007, the FDA announced it had received post-marketing reports that patients using varenicline in search smoking cessation had knowledgeable various pensive side-effects, including suicidal ideation and random suicidal behavior, erratic behavior, and drowsiness. On February 1, 2008 the FDA issued an wide awake to fresh shed its findings, noting that "it appears increasingly like as not that there is an association between Chantix and significant neuropsychiatric symptoms". It is unidentified whether the psychiatric symptoms are linked to the cure or to nicotine withdrawal symptoms,[citation needed - although not all patients had stopped smoking. The FDA also recommended that health misery professionals and patients watch quest of behavioral and spirit changes.[7 - In May 2008, Pfizer updated the aegis communication associated with varenicline, noting that "some patients keep reported changes in behavior, agitation, depressed well-disposed, suicidal thoughts or actions."[8 -
As of July 1, 2009, the US Food and Hypnotic Dispensation requires Chantix (varenicline) to convey a black crate tip, the medium's strongest safety caution, proper to public reports of side effects including despair, suicidal thoughts, and suicidal actions.[9 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| PhilipKt | Дата: Суббота, 11.04.2015, 05:16 | Сообщение # 51 |
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| AlisaBerne | Дата: Суббота, 15.12.2018, 17:18 | Сообщение # 52 |
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